<p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif"><span style="color:#212121">Dr. Çobanoğlu, SANKO Üniversitesi Sani Konukoğlu Uygulama ve Araştırma Hastanesinde düzenlenen konferansta, y</span></span></span><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">eni bir ilacın keşif maliyetinin her 9 yılda yaklaşık iki katına çıktığını söyledi.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">1950’lerden bugüne kadar süren bu artışın, günümüzde yeni bir ilacın maliyetinin 2 milyar doları geçmesine yol açtığını belirten Dr. Çobanoğlu, “Bu maliyetin temel sebebi, klinik denemelere giren ilaç adaylarının yaklaşık yüzde 90’ının başarısız olmasıdır. Onkoloji, sadece yüzde 5 olan başarı oranı ile ilaç keşfinin en zor olduğu alandır” dedi.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">Bu maliyetlerin doğal sonucu olarak, en son onaylanan kanser ilaçlarının bir yıllık maliyetinin yüz bin doların üzerinde olduğunu kaydeden Dr. Çobanoğlu, “Bu da haliyle hastaların yeni tedavilere erişimini oldukça güçleşmiştir” diye konuştu.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">Çobanoğlu Laboratuvarı’nın amacının bu durumu değiştirmek olduğunu anımsatan Dr. Çobanoğlu, şöyle devam etti:</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">“Bize göre bu sorunun temelinde erken aşamalarda indirgemeci deney düzeneklerinin kullanılması yatmaktadır. Yüksek sayıda ilaç test edebilmek amacıyla kurulan basit düzenekler, klinikte elde edilen sonuçlarla çoğu zaman başarılı şekilde örtüşmemektedir.”</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">Dr. Çobanoğlu, bu amaçla yürüttüğü çalışmalarını şöyle özetledi:</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">“1. Kanser tiplerine özel hassasiyetlerin tanımlanması ve bu hassasiyetleri hedef alacak ilaç tahmini,</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">2. Kliniği iyi yansıtan ilaç deneyi düzenekleri geliştirilmesi,</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">3. Kanser dokusu ve normal doku gibi iki farklı örnekte regülatör çıkarımı yapabilmek için diferansiyel regülatör analizi yöntemi,</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">4. Tek hücreli RNA dizilemesi verisi için hücre sınıflandırma ve kümeleme yöntemi.”</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">Dr. Çobanoğlu, konuşmasında erken bir başarı hikayesi olarak, şu anda tedavisi olmayan deri kanserlerinde etki gösteren bir ilaç adayı keşfini de sundu.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p style="margin:0px; -webkit-text-stroke-width:0px; text-align:justify"><span style="font-size:small"><span style="background:white"><span style="color:#222222"><span style="font-family:Arial, Helvetica, sans-serif"><span style="font-style:normal"><span style="font-variant-ligatures:normal"><span style="font-variant-caps:normal"><span style="font-weight:400"><span style="letter-spacing:normal"><span style="orphans:2"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:2"><span style="word-spacing:0px"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="font-size:12pt"><span style="font-family:Arial, sans-serif">Akademisyenlerin ve öğrencilerin yoğun ilgi gösterdiği konferansın sonunda konuşmasının ardından Dr. Çobanoğlu, katılımcıların sorularını cevapladı.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>